Applications of Sulfonyl Fluorides

“点击化学”的概念既具有潜在的变革性，又具有诱人的简单性。自从2014年Sharpless将“点击反应”，扩展到涉及磺酰氟化物的反应，即六价硫氟(VI)交换反应(SuFEx)。基于高价有机硫的特殊反应活性–稳定性平衡(Stability-Reactivity)，六价硫氟(VI)交换反应(SuFEx)是下一代点击反应的一个很有前途的领域。在各种硫(VI)卤化物中，磺酰氟化物是SuFEx点击反应中最受欢迎的连接枢纽，因其独特的性质和广泛的应用，近年来受到越来越多的研究关注。磺酰氟化物由于其平衡的潜在反应性和稳定性以及与生物系统的相容性，已成为有机合成、药物发现和材料化学领域的重要合成中间体和基石。本文详细阐述磺酰氟化合物在有机合成中的应用，并简要介绍其在材料科学和医药学领域的应用。The concept of “click chemistry” is both potentially transformative and temptingly simple. Since 2014, Sharpless has extended the “click reaction” to the reaction involving sulfonyl fluorides, namely the hexavalent sulfur fluorine (VI) exchange reaction (SuFEx). Based on the special reactivity-stability balance (Stability-Reactivity) of high-valent organic sulfur, the hexavalent sulfur-fluorine (VI) exchange reaction (SuFEx) is a promising field for the next-generation click reaction. Among various sulfur (VI) halides, sulfonyl fluorides are the most popular connection hubs in SuFEx click reactions. Due to their unique properties and wide applications, sulfonyl fluorides have attracted more and more attention in recent years. Sulfonyl fluorides have become important synthetic intermediates and cornerstones in the fields of organic synthesis, drug discovery and materials science due to their balanced potential reactivity and stability and compatibility with biological systems. In this paper, the application of sulfonyl fluoride compounds in organic synthesis is described in detail, and its application in materials science and medicine is briefly introduced.