Combination of Sodium Butyrate and Immunotherapy in Glioma: regulation of immunologically hot and cold tumors via gut microbiota and metabolites
We discovered that deacetylation-associated gene expression is significantly increased in glioma patients and affects patient survival time. Moreover, we found sodium butyrate promoted glioma cell apoptosis, disrupted the cell cycle, and inhibited tumor growth. Additionally, sodium butyrate may upregulate PD-L1 expression in glioma cells by modulating the PI3K/AKT pathway. The experimental results demonstrated that this combination therapy significantly reduced tumor volume and prolonged survival in an orthotopic murine glioma model. Moreover, combination therapy led to an increase in the proportion of probiotic bacteria in the mouse gut microbiota, resulting in elevated levels of antitumor metabolites and a decrease in metabolites that affect immune cell function.
Authors
- Cheng Peng
- Guo‐Bo Li (ORCID: https://orcid.org/0000-0002-4915-6677)
- Zhaokai Zhou (ORCID: https://orcid.org/0000-0001-6628-3750)
- Junrong Du (ORCID: https://orcid.org/0000-0003-3320-5785)
- Hailin Tang (ORCID: https://orcid.org/0000-0002-3206-782X)
- Huali Fan (ORCID: https://orcid.org/0000-0002-2476-5898)
- Li Sui
- Mingyu Han (ORCID: https://orcid.org/0000-0001-5459-9782)
- Huile Gao (ORCID: https://orcid.org/0000-0002-5355-7238)
- Zheng Xu (ORCID: https://orcid.org/0000-0003-4276-5100)
- Peng Fu (ORCID: https://orcid.org/0000-0003-0430-5621)
- Li Wang (ORCID: https://orcid.org/0000-0003-2068-7535)
Institutions
- Sun Yat-sen University (CN)
- Sichuan University (CN)
- Sun Yat-sen University Cancer Center (CN)
- Institute of Bioinformatics and Applied Biotechnology (IN)
- First Affiliated Hospital of Zhengzhou University (CN)
- State Key Laboratory of Biotherapy
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-14
- DOI
- https://doi.org/10.3389/fimmu.2025.1532528
- Citations
- 13
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 7.51
Funders
- Department of Science and Technology of Sichuan Province
- State Administration of Traditional Chinese Medicine of the People's Republic of China
- Sichuan Provincial Administration of Traditional Chinese Medicine