Superficial CD34 Positive Fibroblastic Tumor: A rare mesenchymal tumor of borderline malignant potential.

Superficial CD34 positive fibroblastic tumor is a rare soft tissue tumor first brought to light by Jodi M Carter in 2014. Several cases have been reported since, and they have been newly included in the recent WHO classification under the fibroblastic and myofibroblastic tumors category. It is a mesenchymal neoplasm of borderline malignant potential predominantly found in middle-aged adults with a median age of 37 years and most commonly located in the lower extremities. It is a spindle cell tumor with pleomorphic epithelioid cells, low mitotic activity, and strong diffuse positivity for CD34 on immunohistochemistry. The prognosis is good post excision but needs long-term follow-up since few cases revealed recurrences and lymph node metastases. As far as we know, only 64 cases have been documented thus far. We have reported a 63-year female with essential histological features of superficial CD34 positive fibroblastic tumor with no local recurrence or metastasis to date.

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Publication Details

Journal
Journal of Pathology of Nepal
Published
2024-12-31
DOI
https://doi.org/10.3126/jpn.v14i2.64485
Primary Topic
Soft tissue tumor case studies
Type
article
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article

Superficial CD34 Positive Fibroblastic Tumor: A rare mesenchymal tumor of borderline malignant potential.

Jayashri Chaudhari, Manisha Khare, Pradnya Kamble
Journal of Pathology of Nepal
Soft tissue tumor case studies
article

Superficial CD34 Positive Fibroblastic Tumor: A rare mesenchymal tumor of borderline malignant potential.

Jayashri Chaudhari, Manisha Khare, Pradnya Kamble
article en

Abstract

Superficial CD34 positive fibroblastic tumor is a rare soft tissue tumor first brought to light by Jodi M Carter in 2014. Several cases have been reported since, and they have been newly included in the recent WHO classification under the fibroblastic and myofibroblastic tumors category. It is a mesenchymal neoplasm of borderline malignant potential predominantly found in middle-aged adults with a median age of 37 years and most commonly located in the lower extremities. It is a spindle cell tumor with pleomorphic epithelioid cells, low mitotic activity, and strong diffuse positivity for CD34 on immunohistochemistry. The prognosis is good post excision but needs long-term follow-up since few cases revealed recurrences and lymph node metastases. As far as we know, only 64 cases have been documented thus far. We have reported a 63-year female with essential histological features of superficial CD34 positive fibroblastic tumor with no local recurrence or metastasis to date.

Journal of Pathology of NepalVol. 14(2)
Cooper Hospital (IN)
Openalex Percentile: Top 56%
Soft tissue tumor case studies
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