The Role of Blood Inflammatory Biomarkers and Perineural and Lympho-Vascular Invasion to Detect Occult Neck Lymph Node Metastases in Early-Stage (T1-T2/N0) Oral Cavity Carcinomas
Our results confirm that inflammatory biomarkers and perineural and lympho-vascular invasion are effective in detecting occult neck metastases in early-stage OCCs. The clinical relevance of this study is that these parameters could be used routinely as preoperative tools to support diagnosis and to help surgeons in the decision-making process, particularly regarding surgical indications for neck lymph nodes treatment.
Authors
- Vincenzo Abbate (ORCID: https://orcid.org/0000-0002-7905-0531)
- Giovanni Salzano (ORCID: https://orcid.org/0000-0003-3947-8733)
- Giovanni Dell’Aversana Orabona (ORCID: https://orcid.org/0000-0001-6479-6130)
- Riccardo Nocini (ORCID: https://orcid.org/0000-0001-5086-4390)
- Daniela Pacella (ORCID: https://orcid.org/0000-0003-2343-5069)
- Stefania Staibano (ORCID: https://orcid.org/0000-0003-4993-9388)
- Stefania Troise (ORCID: https://orcid.org/0000-0001-8421-0328)
- Paola Bonavolontà (ORCID: https://orcid.org/0000-0002-3326-4825)
- Giulia Togo
- Rosa Maria Di Crescenzo (ORCID: https://orcid.org/0000-0003-0404-0141)
- Carlos Navarro Cuéllar (ORCID: https://orcid.org/0000-0001-9869-9240)
- Raffaele Merola (ORCID: https://orcid.org/0000-0002-0159-1426)
- Fabio Di Blasi
- Maria Esposito (ORCID: https://orcid.org/0000-0001-7095-7957)
Institutions
- University of Verona (IT)
- Universidad Complutense de Madrid (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- Federico II University Hospital (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Cancers
- Published
- 2025-04-12
- DOI
- https://doi.org/10.3390/cancers17081305
- Citations
- 4
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 7.39