A population-based cohort study of mitochondrial disease and mental health conditions in Ontario, Canada
This study presents the first comprehensive, population-wide cohort study of mitochondrial disease and co-prevalent mental health conditions. Our findings demonstrate a high burden of mental health conditions among mitochondrial disease patients, with high associated health care needs. We also find that patients with concurrent mental illness and mitochondrial disease represent a high-burden, high-cost population in a single-payer health insurance setting.
Authors
- Ana C. Andreazza (ORCID: https://orcid.org/0000-0002-4323-7273)
- Thomas D. Samson (ORCID: https://orcid.org/0000-0002-6725-1379)
- Emmalin Buajitti (ORCID: https://orcid.org/0000-0002-3194-7331)
- L. Trevor Young (ORCID: https://orcid.org/0000-0003-0409-5468)
- Mackenzie Hurst
- Laura C. Rosella (ORCID: https://orcid.org/0000-0003-4867-869X)
Institutions
- Centre for Addiction and Mental Health (CA)
- University of Toronto (CA)
- Trillium Health Centre (CA)
- Public Health Ontario (CA)
- McGill University (CA)
- MRC Mitochondrial Biology Unit (GB)
Publication Details
- Journal
- Orphanet Journal of Rare Diseases
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1186/s13023-025-03688-2
- Citations
- 1
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Canada Research Chairs
- University of Toronto