Is aspirin effective and safe for venous thromboembolism prophylaxis after total hip and knee replacement?

Although aspirin is established as an effective prophylaxis for VTE after TJA, there is no consensus as to whether low-or regular-dose aspirin is more effective in preventing VTE.In a retrospective study including 7,488 patients, no significant difference was observed in the incidence of symptomatic VTE after THA with low-dose versus standard-dose aspirin.In the absence of compelling evidence to the contrary, low-dose aspirin appears to be a reasonable option for VTE prophylaxis in otherwise healthy patients undergoing elective THA. [8] conclusion, low-dose aspirin in patients with limited comorbidities undergoing primary THA and TKA is associated with significant lower rates of bleeding and suture reactions than high dose aspirin.Low-dose aspirin is not inferior to higher-dose aspirin for the prevention of VTE, wound complications, and infection on postoperative Day 90. [9]