Reduction in Liver Cancer Risk by Quercetin via Modulation of Urate Levels: Insights from Drug-Target Mendelian Randomization
Considering quercetin's multifaceted interactions with BCRP/<i>ABCG2</i>, our findings support its potential use as a preventive dietary supplement for hepatic diseases rather than as an adjunctive therapy for established liver cancer.
Authors
- Zhengwen Li (ORCID: https://orcid.org/0009-0007-4486-0386)
- Ming Zhang (ORCID: https://orcid.org/0000-0003-2728-128X)
- Yue Wang (ORCID: https://orcid.org/0000-0001-6936-5081)
- Chujie Li (ORCID: https://orcid.org/0000-0002-3362-072X)
- Kaichuan Yang (ORCID: https://orcid.org/0000-0003-3044-2240)
Institutions
- Hainan University (CN)
- Maastricht University (NL)
- Chengdu University (CN)
Publication Details
- Journal
- Genes
- Published
- 2025-04-13
- DOI
- https://doi.org/10.3390/genes16040449
- Citations
- 5
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 7.59
Funders
- National Natural Science Foundation of China