Regulation of Hazelnut Leaf Polyphenols on Oxidative Stress in Chronic Alcoholic Liver Injury

ABSTRACT This study aims to investigate the role of hazelnut leaf polyphenols (HLP) in regulating chronic alcoholic liver damage (CALD) and explore its possible molecular mechanisms. By measuring the scavenging rates of DPPH·, ABTS + , and ·OH, as well as the reducing power and total antioxidant capacity, the antioxidant activity of HLP was evaluated. Both in vivo and in vitro experiments were conducted to examine the effects of HLP on CALD. The results showed that HLP exhibits strong antioxidant activity and within a certain concentration range, can regulate ethanol‐induced oxidative stress levels in LO2 cells. Additionally, HLP improves liver function by modulating the Nrf2/Keap1 pathway, reducing ALT and AST levels in mice, and correcting the body's redox imbalance. This protective effect helps shield the liver from ethanol‐induced damage, revealing that hazelnut leaf polyphenols possess potent antioxidant properties and significantly improve CALD.