The in Vitro Anti-Inflammatory and Antioxidant Activitites of the Bark Extracts from Castanea Mollissima in Vietnam

Evaluation results of anti-inflammatory effects through the inhibition of NO production in RAW264.7 macrophages and antioxidant activity using the DPPH method of the crude extract (TK); fractional extracts: n-hexane (TKH), ethyl acetate (TKE) and methanol (TKM) of the bark Castanea mollissima in Vietnam as follows: The crude extract (TK) exhibited good anti-inflammatory and antioxidant activities in vitro with SC50 value of 29.13 µg/mL and IC50 value of 19.6 µg/mL, respectively. Fractionated extract, ethyl acetate (TKE) exhibited the best anti-inflammatory and antioxidant activities in vitro with SC50 value of 21.67 µg/ml and IC50 value of 17.4 µg/ml, respectively. The remaining fractions showed moderate and weak activity. The above results guide further research on chemical composition and anti-inflammatory and antioxidant activities in the future of the Castanea mollissima in Vietnam.