Alterations in the gut microbiome and metabolome in elderly patients with postoperative delirium: A prospective nested case-control study
This study identified four preoperative bacterial genera and four postoperative plasma metabolites associated with an increased risk of POD in elderly orthopedic patients, suggesting the potential of gut microbiota and metabolite profiles as biomarkers for improving risk prediction and guiding interventions.
Authors
- Xinyu Hao (ORCID: https://orcid.org/0000-0002-0634-3333)
- Zhikang Zhou (ORCID: https://orcid.org/0000-0002-4298-3856)
- Jiang Huo
- Shuping Han (ORCID: https://orcid.org/0000-0003-2077-1673)
- Hao Li (ORCID: https://orcid.org/0000-0002-9377-1706)
- Yanhong Liu (ORCID: https://orcid.org/0000-0003-0749-2602)
- Weidong Mi (ORCID: https://orcid.org/0000-0002-5606-6450)
- Yingqun Yu
- Jiangbei Cao (ORCID: https://orcid.org/0000-0003-1218-4639)
- Jingsheng Lou
Institutions
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- Journal of Clinical Anesthesia
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1016/j.jclinane.2025.111833
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00