Visible Light‐Mediated C─H Monofluoromethylation of (Hetero)Arenes
Abstract We report the design and application of a monofluoromethylation reagent: 1‐((bromofluoromethyl)sulfonyl)‐4‐chlorobenzene. By taking advantage of the electron‐withdrawing property of the sulfonyl group, the polarity of the monofluoride radical can be regulated; moreover, the sulfonyl group's facile removability is exploited. These combined features enable direct monofluoromethylation of (hetero)arenes under mild visible‐light conditions.
Authors
- Liu Hon (ORCID: https://orcid.org/0000-0002-2560-6282)
- Xin Liu (ORCID: https://orcid.org/0000-0002-4918-9890)
- Yingsheng Zhao (ORCID: https://orcid.org/0000-0002-2994-8474)
- Huiming Dai
- Xuefeng Gu
- Yilian Song
- Chuangchuang Liu
- Zhibin Huang
Institutions
- Soochow University (TW)
- Soochow University (CN)
- Institute of New Materials (CN)
Publication Details
- Journal
- Asian Journal of Organic Chemistry
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1002/ajoc.202500297
- Citations
- 1
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.79
Funders
- National Natural Science Foundation of China
- Priority Academic Program Development of Jiangsu Higher Education Institutions