Protective effect of nano magnesium oxide on renal ischemia/reperfusion injury in male Wistar rats

Ischemia/reperfusion (I/R) injury is a main issue in renal transplantation, and antioxidants attenuate I/R injury in different tissues. We investigated the protective effects of nano magnesium oxide (nano-MgO) on renal I/R injury in rats. Induction of I/R injury was performed through clamping the left renal pedicle for 20 minutes. Animals were administrated with nano-MgO (1.25, 2.5 and 5 mg/kg) for 30 days by gavage, and were sacrificed for biochemical and histopathological studies. Our findings show that nano-MgO administration (2.5 and 5 mg/kg) in rats with renal I/R injury significantly attenuated serum creatinine and urea levels (p<0.001), decreased malondialdehyde (MDA) levels and elevated antioxidant enzyme activities in renal homogenates (p<0.001), as evidenced by histopathological assessment, and caused a significant reduction in EGF immunoreactivity and EGFR expression in renal tissues (p<0.001). In conclusion, nano-MgO administration preserves renal function and prevents tissue damage after I/R injury in rats.