A finite element study of the biomechanics of aging osteocyte model

Aging lacuna-canalicular system (LCS) has osteocyte size reduction, cell process number loss, and canaliculus blockage. This study built four osteocyte aging models for various aging features. These models have processes, collagen hillocks, and primary cilia mechanoreceptors for signal comparison. A triaxial displacement load on the piezoelectric bone matrix was utilized to explore mechanical signal changes in the absence of different processes, canaliculi blockage, and the effects of aging on osteocyte mechanoreceptor signals. Osteocyte age doesn't affect piezoelectric effect electric field strength. The aging model flows slower than the normal model. Blocking canaliculi raises fluid pressure. Aging osteocytes lack processes, reducing primary cilia and process stress-strain. Osteocyte volume reduction and canaliculi blockage exacerbate this alteration.

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Publication Details

Journal
Computer Methods in Biomechanics & Biomedical Engineering
Published
2025-04-14
DOI
https://doi.org/10.1080/10255842.2025.2479853
Primary Topic
Cellular Mechanics and Interactions
Type
article
Field-Weighted Citation Impact
0.00

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article

A finite element study of the biomechanics of aging osteocyte model

Xiaogang Wu, Pengcui Li, Weiyi Chen, Yanqin Wang et al.
Computer Methods in Biomechanics & Biomedical Engineering
Cellular Mechanics and Interactions
article

A finite element study of the biomechanics of aging osteocyte model

Xiaogang Wu, Pengcui Li, Weiyi Chen, Yanqin Wang, Jiajun Wang, Jing Chen, Meng Zhang, Xiaochun Wei, Yongxing Wang, Xiyu Wang, Zhengbiao Yang, Yanru Xue
article en

Abstract

Aging lacuna-canalicular system (LCS) has osteocyte size reduction, cell process number loss, and canaliculus blockage. This study built four osteocyte aging models for various aging features. These models have processes, collagen hillocks, and primary cilia mechanoreceptors for signal comparison. A triaxial displacement load on the piezoelectric bone matrix was utilized to explore mechanical signal changes in the absence of different processes, canaliculi blockage, and the effects of aging on osteocyte mechanoreceptor signals. Osteocyte age doesn't affect piezoelectric effect electric field strength. The aging model flows slower than the normal model. Blocking canaliculi raises fluid pressure. Aging osteocytes lack processes, reducing primary cilia and process stress-strain. Osteocyte volume reduction and canaliculi blockage exacerbate this alteration.

Computer Methods in Biomechanics & Biomedical Engineering
Taiyuan University of Technology (CN)
National Natural Science Foundation of China, China Postdoctoral Science Foundation, Program for the Scientific Activities of Selected Returned Overseas Professionals in Shaanxi Province, Graduate Research and Innovation Projects of Jiangsu Province
Zero hunger
Openalex Percentile: Top 92%
Cellular Mechanics and Interactions
DOISourceOpenAlex
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