Deuteration of organic compounds by electrolysis of glucose-heavy water using a graphene oxide membrane reactor
This study explores the cost-effective synthesis of deuterium-labelled compounds <i>via</i> electrolysis of glucose-heavy water (D<sub>2</sub>O) employing a proton-conducting graphene oxide membrane (GOM) with Pt/C and IrO<sub>2</sub>/Al<sub>2</sub>O<sub>3</sub>. C(sp<sup>3</sup>)-H bonds of mono, double, and triple methyl groups in aromatic compounds were successfully deuterated with high deuterium incorporation (%) and excellent yield (%).
Authors
- Takeru Nakahara
- Armando T. Quitain (ORCID: https://orcid.org/0000-0003-1051-3726)
- Yusuke Inomata (ORCID: https://orcid.org/0000-0002-1517-966X)
- Tetsuya Kida (ORCID: https://orcid.org/0000-0001-9357-9557)
- Muhammad Sohail Ahmad
- Prasert Reubroycharoen (ORCID: https://orcid.org/0000-0002-4968-6539)
- Imam Sahroni (ORCID: https://orcid.org/0000-0003-2554-9895)
- Taiga Kodama
- Muhammad Fadil (ORCID: https://orcid.org/0009-0007-6680-7308)
- Ghina Kifayah Putri
- A. Takase (ORCID: https://orcid.org/0009-0006-1421-8774)
- Le Mai Hong Tham
Institutions
- Chulalongkorn University (TH)
- Islamic University of Indonesia (ID)
- Kumamoto Industrial Research Institute (JP)
- Kumamoto University (JP)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc01646k
- Primary Topic
- Chemical Reactions and Isotopes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Takahashi Industrial and Economic Research Foundation
- Marubun Research Promotion Foundation