Early detection of cognitive impairment in end-stage renal disease patients undergoing hemodialysis: insights from Resting-State functional connectivity analysis
In conclusion, our study reveals multiple abnormal FC regions in asymptomatic ESHD patients, affecting visual-spatial processing, short-term memory, language, attention, and executive function. Altered FCs and their negative correlation with serum calcium levels highlight a potential link between metabolic disturbances and cognitive decline, suggesting new opportunities for targeted interventions in this vulnerable population.
Authors
- Yi Yin (ORCID: https://orcid.org/0000-0003-4750-4997)
- Wenqing Xiao
- Zichao Chen
- Shandong Meng
- Shoujun Xu (ORCID: https://orcid.org/0000-0002-5182-9375)
- Rujin Li
- Mengchen Liu
- Kanghui Yu
- Weizhao Lin (ORCID: https://orcid.org/0000-0001-8189-5894)
- Jiejing Li (ORCID: https://orcid.org/0000-0001-9020-512X)
- Zhihua Zhou (ORCID: https://orcid.org/0000-0001-6262-6365)
- Yunfan Wu (ORCID: https://orcid.org/0000-0001-6994-6791)
- Guihua Jiang (ORCID: https://orcid.org/0000-0002-8344-7670)
- Man Liang
- Yanying Chen (ORCID: https://orcid.org/0000-0001-7996-0677)
Institutions
- Jinan University (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- First Affiliated Hospital of Guangdong Pharmaceutical University (CN)
- Guangdong Provincial People's Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- BMC Nephrology
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1186/s12882-025-04109-z
- Citations
- 1
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.43