Additional Diagnostic Yield of Ambulatory 24‐h High Resolution Manometry With Impedance in Patients With Non‐Cardiac Chest Pain or Non‐Obstructive Dysphagia

24-h-HRM revealed spastic and/or hypercontractile esophageal motor disorders in about 60% of patients with NCCP/NOD and markedly improved diagnostic yield compared with standard HRM, probably partly due to the observed circadian variability of esophageal motility. 24-h-HRM findings frequently altered treatment recommendations, but the ultimate clinical consequences of the increased diagnostic yield have to be examined further.