Ultrasound and Microbubble Mediated Delivery of Virus-Sensitizing Drugs Improves In Vitro Oncolytic Virotherapy Against Breast Cancer Cells
Altogether, our data show that drug-loaded microbubble cavitation and free drugs both sensitize cancer cells to oncolytic viruses to equivalent levels. These findings provide a proof of concept for the use of ultrasound-guided microbubble drug delivery in combination with oncolytic virotherapy.
Authors
- Kishan S. Italiya
- Karen Geoffroy (ORCID: https://orcid.org/0000-0002-6093-349X)
- Victoria H. Gilchrist
- Marie‐Claude Bourgeois‐Daigneault (ORCID: https://orcid.org/0000-0002-9091-2235)
- François T.H. Yu (ORCID: https://orcid.org/0000-0001-9325-017X)
- Tommy Alain (ORCID: https://orcid.org/0000-0002-0396-9138)
- Victor Mullins‐Dansereau (ORCID: https://orcid.org/0000-0003-2744-9986)
Institutions
- Children's Hospital of Eastern Ontario (CA)
- Institute for Research in Immunology and Cancer (CA)
Publication Details
- Journal
- Ultrasound in Medicine & Biology
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1016/j.ultrasmedbio.2025.03.010
- Citations
- 6
- Primary Topic
- Ultrasound and Hyperthermia Applications
- Type
- article
- Field-Weighted Citation Impact
- 4.04
Funders
- Cancer Research Society
- Fondation du cancer du sein du Québec
- Government of Canada
- Terry Fox Foundation
- Natural Sciences and Engineering Research Council of Canada
- Fonds de Recherche du Québec - Santé
- Institute of Cancer Research