Expression of BCL-2 and Laminin in Rectosigmoid Hirschsprung Disease: Correlations with Hirschsprung−Associated Enterocolitis
This is the first study to examine the correlation between BCL-2 and Laminin expression changes and enterocolitis developing in HD. It is a previously unreported contribution to the literature that BCL-2 mRNA expression was lower than expected in all intestinal tissues of HD patients, including the intestinal tissues considered to be healthy. Mutagenic changes have been detected in the BCL-2 gene of some HD patients. A definitive novel mutation, which has not been reported in the literature before, was detected in one patient.
Authors
- Rumeysa Fatma Balaban (ORCID: https://orcid.org/0000-0001-7710-7613)
- Nesrin Uğraş (ORCID: https://orcid.org/0000-0003-0127-548X)
- Merve Dede (ORCID: https://orcid.org/0000-0003-2346-7802)
- Gülşah Çeçener (ORCID: https://orcid.org/0000-0002-3820-424X)
- Ufuk Ünal (ORCID: https://orcid.org/0000-0003-4913-3616)
- Fatih Çelik (ORCID: https://orcid.org/0000-0002-7960-4477)
- İrfan Kırıştıoğlu (ORCID: https://orcid.org/0000-0002-7244-6736)
- Ebrucan Bulut
- Nuseybe Huriyet
Institutions
- Bursa Uludağ Üni̇versi̇tesi̇ (TR)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1038/s41390-025-03994-2
- Citations
- 1
- Primary Topic
- Congenital gastrointestinal and neural anomalies
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Bursa Uludağ Üniversitesi