Potential anti-gastric cancer properties of modified Lichong decoction based on metabolomics, network pharmacology, and pharmacological verification
This study evaluated the pharmacological effects of MLCD on gastric cancer. These results suggest that MLCD can exert an anti-gastric cancer effects through multiple targets and pathways and that the PI3k/Akt pathway is an important pathway in the regulation of proliferation, cell cycle, and apoptosis in gastric cancer. The toxic effects of MLCD on tumour-bearing mice were indistinctively observed after continuous administration for 4 weeks.
Authors
- Hongyu Yao (ORCID: https://orcid.org/0000-0002-6626-2682)
- Meiyu Feng
- Zhe Chen (ORCID: https://orcid.org/0000-0002-5303-9879)
- Liwei Ma (ORCID: https://orcid.org/0000-0002-7867-8060)
- Yujing Wang (ORCID: https://orcid.org/0000-0002-4801-1281)
- Guanglu Shi (ORCID: https://orcid.org/0000-0001-5562-111X)
Institutions
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- Heilongjiang Provincial Hospital (CN)
- Qiqihar Medical University (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1016/j.jep.2025.119806
- Citations
- 3
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 2.81