Nickel-catalyzed synthesis of fluorine-bearing silane through halofluoroalkylation and hydrofluoroalkylation of alkenylsilanes
Fluorine-bearing silanes have displayed widespread applications in organic synthesis and inorganic and material chemistry due to their high reactivity and versatility.However, the synthesis of fluorine-containing compounds featuring a difluorine-bearing silane is still underdeveloped.Here, we reported a simple, mild and efficient method for halofluoroalkylation and hydrofluoroalkylation of alkenylsilanes with bromodifluoroacetates under nickel catalysis, affording a variety of fluorine-bearing silanes in up to 89 % yield.This research was distinguished by its good functional group tolerance, moderate to good yields and exclusive regioselectivity.
Authors
- Wenxin Lu (ORCID: https://orcid.org/0000-0001-6388-7743)
- Ting Su (ORCID: https://orcid.org/0000-0001-6292-1209)
- Qinglei Chong
- Fanke Meng (ORCID: https://orcid.org/0000-0003-1009-631X)
- Wei Huang (ORCID: https://orcid.org/0009-0005-3493-4228)
- Heng Wang (ORCID: https://orcid.org/0009-0009-8686-4566)
Institutions
- University of California, Santa Barbara (US)
- Yale University (US)
- Shanghai Institute of Organic Chemistry (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Tetrahedron Chem
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1016/j.tchem.2025.100129
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Science and Technology Commission of Shanghai Municipality
- Nankai University
- Beijing National Laboratory for Molecular Sciences