Integration of amide proton transfer-weighted imaging and methionine positron emission tomography histogram parameters enhances the prediction of isocitrate dehydrogenase mutations in adult diffuse gliomas
Combining histogram-derived parameters from APT-WI and MET-PET significantly improves the diagnostic accuracy for predicting IDH mutation status in diffuse gliomas. This non-invasive approach may serve as a valuable adjunct for preoperative evaluation and the development of personalised treatment strategies in patients with gliomas.
Authors
- Daisuke Kuga (ORCID: https://orcid.org/0000-0002-9493-0748)
- Shingo Baba
- Takuro Isoda
- Osamu Togao (ORCID: https://orcid.org/0000-0002-5910-7852)
- Koji Yamashita (ORCID: https://orcid.org/0000-0002-7417-739X)
- Koji Yoshimoto (ORCID: https://orcid.org/0000-0001-7912-2024)
- Masaoki Kusunoki (ORCID: https://orcid.org/0000-0002-6767-569X)
- Yutaka Fujioka (ORCID: https://orcid.org/0000-0002-8506-9343)
- Motohiro Sando
- Kousei Ishigami (ORCID: https://orcid.org/0000-0001-8107-5570)
- Kazufumi Kikuchi (ORCID: https://orcid.org/0000-0003-1292-1846)
- Yoshiyuki Kitamura (ORCID: https://orcid.org/0000-0002-8852-2895)
- Fumiya Narutomi
Institutions
- Kyushu University (JP)
Publication Details
- Journal
- EJNMMI Reports
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1186/s41824-025-00248-6
- Citations
- 1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- Japan Society for the Promotion of Science