Annual trends in GVHD prophylaxis using ATG in BMT and PBSCT in Japan
Graft-versus-host disease (GVHD) prophylaxis using antithymocyte globulin (ATG) has been well-established in allogeneic hematopoietic stem cell transplantation. We collected data on GVHD prophylaxis from 27,091 cases of hematological malignancies undergoing bone marrow transplantation (BMT) and peripheral blood stem cell transplantation (PBSCT) from 2010 to 2022. Annual trends in GVHD prophylaxis were analyzed based on donor type, stem cell source or HLA compatibility. The number of GVHD prophylaxis using ATG was increased in related-HLA matched-PBSCT [2010: n＝6 (1.6%), 2022: n＝42 (14.1%)], unrelated-HLA matched-PBSCT [2010: n＝0 (0.0%), 2022: n＝80 (43.0%)], unrelated-HLA 1-locus mismatched-BMT [2010: n＝36 (9.6%), 2022: n＝97 (40.4%)], and unrelated-HLA 1-locus mismatched-PBSCT [2010: n＝0 (0.0%), 2022: n＝64 (59.3%)]. Conversely, ATG use decreased in related-HLA haplo-PBSCT [2010: n＝111 (67.7%), 2022: n＝63 (11.2%)] due to the increasing use of posttransplant cyclophosphamide (PTCy). This study highlights the variation in GVHD prophylaxis trends using ATG across transplantation types.
Authors
- Yuta Hasegawa (ORCID: https://orcid.org/0000-0002-9925-2093)
- Noboru Asada (ORCID: https://orcid.org/0000-0001-7322-5460)
- Noriko Doki (ORCID: https://orcid.org/0000-0002-8661-3179)
- Takanori Teshima (ORCID: https://orcid.org/0000-0002-0941-271X)
- Souichi Shiratori (ORCID: https://orcid.org/0000-0002-5528-7112)
- Hirohisa Nakamae (ORCID: https://orcid.org/0000-0003-4203-990X)
- Marie Ohbiki (ORCID: https://orcid.org/0009-0007-3522-2278)
- Yoshinobu Kanda
- Takahiro Fukuda
- Tetsuya Nishida
- Satoshi Yoshihara
- Yoshiko Atsuta
Institutions
- Jichi Medical University (JP)
- Aichi Medical University (JP)
- Hokkaido University (JP)
- Tokyo Metropolitan Komagome Hospital (JP)
- National Cancer Center (US)
- Okayama University Hospital (JP)
- Japanese Red Cross Nagoya Daiichi Hospital (JP)
- Hokkaido University Hospital (JP)
- The Japanese Data Center for Hematopoietic Cell Transplantation (JP)
- Jichi Medical University Saitama Medical Center (JP)
- Osaka Metropolitan University (JP)
- Nagoya University (JP)
- Hyogo University (JP)
Publication Details
- Journal
- Japanese Journal of Transplantation and Cellular Therapy
- Published
- 2025-01-01
- DOI
- https://doi.org/10.7889/tct-24-022
- Primary Topic
- Cardiac Imaging and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00