A Critical Role for the Mitochondrial Pyruvate Carrier in Hepatic Stellate Cell Activation
These data suggest that MPC inhibition modulates HSC metabolism to attenuate activation and illuminate mechanisms by which MPC inhibitors could prove therapeutically beneficial for treating MASH.
Authors
- Kim Liss (ORCID: https://orcid.org/0000-0001-6915-1163)
- Andrew J. Lutkewitte (ORCID: https://orcid.org/0000-0001-7271-246X)
- Daniel Ferguson (ORCID: https://orcid.org/0000-0003-0336-8487)
- Andrea Bredemeyer (ORCID: https://orcid.org/0000-0003-2970-5998)
- Gary J. Patti (ORCID: https://orcid.org/0000-0002-3748-6193)
- Trevor M. Shew
- Kevin Cho (ORCID: https://orcid.org/0000-0002-3041-3506)
- Mandy M. Chan (ORCID: https://orcid.org/0000-0001-6511-0962)
- Terri Pietka (ORCID: https://orcid.org/0000-0003-0160-7261)
- Andrew LaPoint
- Christina Fu (ORCID: https://orcid.org/0000-0001-5555-3874)
- Sophie J. Eichler
- Mai He (ORCID: https://orcid.org/0000-0002-4775-9757)
- Mohammad Habibi (ORCID: https://orcid.org/0000-0002-0779-1445)
- Joel D. Schilling (ORCID: https://orcid.org/0000-0002-3884-1994)
- Brian N. Finck (ORCID: https://orcid.org/0000-0001-5411-3674)
Institutions
- Washington University in St. Louis (US)
- University of Kansas Medical Center (US)
- University of Missouri–Kansas City (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101517
- Citations
- 2
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 2.64
Funders
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Center for Environmental Health