Continuous versus intermittent bolus dosing of beta-lactam antibiotics in a South African multi-disciplinary intensive care unit: A randomized controlled trial
Among critically ill patients meeting the sepsis-3 definition, this study could not demonstrate the superiority of continuous infusion of beta-lactam antibiotics compared to intermittent bolus in achieving a clinical cure.
Authors
- Mohd H. Abdul‐Aziz (ORCID: https://orcid.org/0000-0002-8889-5579)
- Shahed Omar (ORCID: https://orcid.org/0000-0001-8494-1518)
- Jeffrey Lipman (ORCID: https://orcid.org/0000-0002-5965-9876)
- Linda Hindle
- Fetolang Simelela
- Ayesha Khan (ORCID: https://orcid.org/0000-0002-3105-3522)
Institutions
- The University of Queensland (AU)
- Royal Brisbane and Women's Hospital (AU)
- Chris Hani Baragwanath Hospital (ZA)
Publication Details
- Journal
- Journal of Infection
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1016/j.jinf.2025.106487
- Citations
- 5
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 6.97