Cerebrospinal fluid concentrations of ceftaroline and ceftazidime/avibactam in healthy volunteers: Pharmacokinetics and probability of target attainment
In healthy subjects, ceftaroline, ceftazidime and avibactam poorly distribute to CSF. Nonetheless, CSF exposure of both cephalosporins might be sufficient to cover certain, but not all, pathogens causative of CNS infections.
Authors
- Beatrix Wulkersdorfer
- Peter Wohlrab (ORCID: https://orcid.org/0000-0001-8516-938X)
- Birgit Reiter (ORCID: https://orcid.org/0000-0002-5352-4161)
- Ulrich Rabl
- Markus Zeitlinger (ORCID: https://orcid.org/0000-0002-1873-3953)
- Wisse van Os (ORCID: https://orcid.org/0000-0003-1709-4173)
- Martin Bauer (ORCID: https://orcid.org/0000-0003-4818-1560)
- Felix Bergmann (ORCID: https://orcid.org/0000-0002-1224-9036)
- Valentin al Jalali (ORCID: https://orcid.org/0000-0002-9196-1936)
- Thomas Stimpfl (ORCID: https://orcid.org/0000-0003-0418-1809)
- Michael Wölfl‐Duchek
- Peter Marhofer (ORCID: https://orcid.org/0000-0002-1647-3780)
- Edith Lackner
- Anselm Jorda
Institutions
- Medical University of Vienna (AT)
Publication Details
- Journal
- International Journal of Antimicrobial Agents
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1016/j.ijantimicag.2025.107512
- Citations
- 1
- Primary Topic
- Bacterial Infections and Vaccines
- Type
- article
- Field-Weighted Citation Impact
- 1.18
Funders
- Pfizer