The mechanism underlying of Zuoguiyin on liver and kidney in D-gal-induced subacute aging female rats: A perspective on SIRT1-PPARγ pathway regulation of oxidative stress, inflammation and apoptosis
This study reveals that ZGY exerts positive effects on the liver and kidney in D-gal-induced subacute aging female rats. Its mechanisms are associated with the activation of the SIRT1-PPARγ pathway, which regulates oxidative stress, inflammation, and apoptotic pathways.
Authors
- Baobao Li (ORCID: https://orcid.org/0000-0001-8256-4632)
- Guoqi Zhu (ORCID: https://orcid.org/0000-0001-7432-6079)
- Jingji Wang (ORCID: https://orcid.org/0000-0003-1366-8600)
- Peiyang Sun
- Jichun Xie (ORCID: https://orcid.org/0000-0001-5905-6728)
- Shaojie Yang
- Shubin Yang
- Chao He (ORCID: https://orcid.org/0000-0002-4629-4740)
Institutions
- Heilongjiang University of Chinese Medicine (CN)
- Anhui Medical University (CN)
- Anhui University of Traditional Chinese Medicine (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1016/j.jep.2025.119811
- Citations
- 5
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.89
Funders
- National Natural Science Foundation of China