Pot‐Economical Synthesis of Fluorinated Pyrrolizinone Derivatives
Abstract A new family of fluorinated dihydropyrrolizinones has been synthesized starting from fluorinated enamino amides and aliphatic conjugated ketones. The reaction comprises a cross metathesis reaction followed by a tandem cycloaromatization/ enamine hydrolysis/ intramolecular Friedel‐Crafts alkylation sequence. This pot‐economical process takes place in good yields (35‐67%), taking into account that it consists of four consecutive reactions. Aromatic enones are also good partners for this protocol although, in this case, the cross metathesis reaction has to be performed in a separated step.
Authors
- Daniel Gaviña (ORCID: https://orcid.org/0009-0004-2048-2921)
- María Sánchez‐Roselló (ORCID: https://orcid.org/0000-0003-0675-3153)
- Carlos del Pozo (ORCID: https://orcid.org/0000-0002-0947-5999)
- Marcos Escolano (ORCID: https://orcid.org/0000-0003-1804-9542)
- Santiago Díaz Oltra
- Lidia Prieto
- Luis Paredes-Soler
Institutions
- University of Alicante (ES)
- Universitat de València (ES)
- Centro de Investigacion Principe Felipe (ES)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1002/adsc.202500209
- Primary Topic
- Synthesis of β-Lactam Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Generalitat Valenciana
- Ministerio de Ciencia e Innovación
- Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital, Generalitat Valenciana