Liver Abscesses in Patients With Beta Thalassaemia Major: A Case Series and Mini-Review of the Literature
Treatment of liver abscesses in patients with transfusion-dependent thalassaemia remains a challenging task due to the interplay of multiple factors, including difficult venous access and the co-existence of other organ dysfunction, such as diabetes mellitus. We report case histories of three transfusion-dependent thalassaemia patients with liver abscesses, two of whom had repeated episodes of the disease. We recommend a prolonged regimen of intravenous and oral antibiotics to eliminate the infection, along with more vigilant and regular follow-up using imaging for early detection of recurrence. Finally, we highlight the importance of maintaining continuous venous access - another often overlooked challenge among thalassaemia patients.
Authors
- Arjuna P. De Silva (ORCID: https://orcid.org/0000-0002-0559-8721)
- Madunil Anuk Niriella (ORCID: https://orcid.org/0000-0002-7213-5858)
- Hithanadura J. de Silva
- Anuja Premawardhena (ORCID: https://orcid.org/0000-0003-0605-9081)
- Kunchana Thebuwana
- Vajira Tharanga Samarawickrama (ORCID: https://orcid.org/0000-0002-9392-7678)
- Nilanga Nishad (ORCID: https://orcid.org/0000-0002-3143-4181)
- Hiruni Jayasena (ORCID: https://orcid.org/0000-0001-5175-0803)
- H. M. U. A. S. Perera
- Dhananja Namalie
Institutions
- University of Kelaniya (LK)
- General Sir John Kotelawala Defence University (LK)
- East Surrey Hospital (GB)
- Colombo North Teaching Hospital (LK)
- Hywel Dda University Health Board (GB)
- Sheffield Teaching Hospitals NHS Foundation Trust (GB)
- Center for Digestive and Liver Diseases (US)
- Surrey and Sussex Healthcare NHS Trust (GB)
- UK Thalassaemia Society (GB)
Publication Details
- Journal
- Cureus
- Published
- 2025-04-14
- DOI
- https://doi.org/10.7759/cureus.82258
- Primary Topic
- Amoebic Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00