The Therapeutic Effects of a High-Velocity Resistance Training Intervention for Chemotherapy-Induced Polyneuropathy

Purpose: Chemotherapy-induced polyneuropathy, also referred to as chemotherapy-induced peripheral neuropathy (CIPN), is a dose-dependent, neurotoxicity from known neuropathic agents (e.g., taxanes, platinums, and vinca alkaloids) causing damage to the peripheral nervous system. CIPN can present as sensory, motor, or autonomic symptoms, such as muscle weakness and balance impairments. Currently, there are no treatment or prevention methods for CIPN. The purpose of this case series was to assess the therapeutic effects of a high velocity resistance training (HVRT), or power training, in women diagnosed and treated for cancer, who presented with CIPN by measuring balance, functional performance, neuropathy, quality of life (QoL), and an inflammatory biomarker (c-reactive protein [CRP]). Methods: The HVRT intervention consisted of 24 exercise sessions over 12 weeks including, upper and lower extremity movements. The intensity prescribed was 30-60% one repetition maximum (1 RM) for upper extremity, and 0-60% 1 RM for lower extremity exercises. Results: Findings demonstrate the feasibility of designing and implementing a HVRT intervention to potentially attenuate CIPN symptoms. Moreover, HVRT may improve balance, functional performance, and QoL outcomes. Although the CRP results increased, the values remained within normal limits, thus lifestyle modifications are needed. Conclusion: This study provides encouraging evidence for a future HVRT intervention pilot study modulating CIPN symptoms. Balance, functional performance, and inflammatory markers should be measured prior to and throughout the treatment of neuropathic agents to better establish baseline values. Further research is needed to enable clinicians to provide comprehensive and effective treatment plans for persons with CIPN, subsequently improving QoL.