Investigation of the Effects of Pentane, Hexane, Heptane, and Octane on Bovine Skin Papillomatosis

The purpose of this study was to determine the effects of pentane, hexane, heptane, and octane on bovine skin papillomatosis. The research was carried out on 50 head of cattle bred in the Ardahan region. The cattle that were infected with papillomatosis were divided into 5 groups of 10 animals each. All cattle in the groups were provided with the same environment and feeding conditions (they were fed ad libitum with grass and tap water from the same source). Group 1 was kept as a control group and received no treatment. Group 2 was sprayed with pentane, Group 3 with hexane, Group 4 with heptane, and Group 5 with octane twice a day (morning and evening) with an atomizer to wet and cover papilloma lesions. This treatment was continued for 15 days. All animals in the groups were clinically examined, and blood samples were collected on day 0 (prior to treatment) and on days 3, 6, 9, 12, and 15. Formula leukocyte and total leukocyte counts were performed on the blood samples. On days 3, 6, 9, 12, and 15, when blood samples were taken, it was seen that the number of lymphocytes in the hexane, heptane, and octane groups was significantly higher (p < 0.05) than it was in the control and pentane groups. The total leukocyte count in the hexane, heptane, and octane groups was significantly higher (p < 0.05) than it was in the control group on day 6 and significantly higher (p < 0.05) than it was in the control and pentane groups on days 9, 12, and 15. In addition, tissue sections from the lesioned areas of the sick animals were taken before and after treatment and examined histopathologically. The lesions were checked daily until day 35 after the treatment began, and the number of animals that had recovered was noted. The control and pentane group animals did not improve by the end of day 35. Improvement was observed in 70% of the hexane group, 80% of the heptane group, and 50% of the octane group. In this study, heptane, hexane, and octane were found to be effective against bovine skin papillomatosis. If the results of the research are supported by other studies, suitable preparations (such as a cream) containing these chemicals or their mixtures can be considered as an alternative method in the treatment of the disease.