Synthesis of Substituted Imidazo[1,2‐<i>a</i>]pyridines, Imidazo[1,2‐<i>a</i>]pyrazines and Imidazo[1,2‐<i>b</i>]pyridazines by Multicomponent Reactions Using Green Solvents

Herein, the synthesis of imidazo[1,2‐ a ]pyridines, imidazo[1,2‐ a ]pyrazines and imidazo[1,2‐ b ]pyridazines by a multicomponent Groebke–Blackburn–Bienaymé reaction is described under sustainable conditions using eucalyptol as green solvent. After determining the optimum conditions for catalysis, a library of 32 compounds with activity on the central nervous system was quickly and efficiently assembled.