The effect of enhancers on the lentiviral transduction efficiency in the human RPE cells: Insights for advancing retinal gene therapies
Pb enhanced the transduction efficiency of lentiviral particles in RPE cells and in combination with PS achieved the highest level of MFI and GFP-positive percentage. Although, the efficiency of the combination was not significant compared to that of individual treatments, this study may suggest the potential of combinational enhancers for applications in gene therapy.
Authors
- Hamid Ahmadieh (ORCID: https://orcid.org/0000-0002-8139-2661)
- Mozhgan Rezaei Kanavi (ORCID: https://orcid.org/0000-0002-1497-2260)
- Javad Ranjbari (ORCID: https://orcid.org/0000-0001-7025-1479)
- Sajad Najafi (ORCID: https://orcid.org/0000-0001-7226-5778)
- Azam Rahimpour (ORCID: https://orcid.org/0000-0002-3296-5881)
- Fatemeh Suri
- Maryam Maleki Tehrani
Institutions
- Shahid Beheshti University of Medical Sciences (IR)
Publication Details
- Journal
- Biochemistry and Biophysics Reports
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1016/j.bbrep.2025.102010
- Citations
- 1
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Shahid Beheshti University of Medical Sciences