Palladium-Catalyzed Hiyama Cross-Coupling of Heterocyclic Phosphonium Salts with Arylsilanes
We report herein the palladium-catalyzed Hiyama cross-coupling of heterocyclic phosphonium salts with diverse (hetero)arylsilanes through C-P bond cleavage, providing an alternative approach for the highly regioselective functionalization of pyridines and relevant nitrogen-containing heterocycles. This silicon-based protocol is amenable to gram-scale synthesis and also applicable to the late-stage functionalization of pharmaceutically relevant complex molecules.
Authors
- Teck‐Peng Loh (ORCID: https://orcid.org/0000-0002-2936-337X)
- Mingzhu Lu (ORCID: https://orcid.org/0000-0002-6333-0803)
- Hongfang Li (ORCID: https://orcid.org/0009-0006-1107-9465)
- Yaqi Liu (ORCID: https://orcid.org/0009-0001-7653-3757)
- Rui Yang (ORCID: https://orcid.org/0009-0007-3053-7078)
Institutions
- Nanyang Technological University (SG)
- Henan University of Technology (CN)
- Huaiyin Normal University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1021/acs.orglett.5c00709
- Citations
- 8
- Primary Topic
- Catalytic Cross-Coupling Reactions
- Type
- article
- Field-Weighted Citation Impact
- 7.49
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province