The Effect of Low-Density Lipoprotein Receptor-Related Protein-1 on Acute Kidney Injury and Renal Tubular Epithelial Triglyceride Accumulation
Our study demonstrated that the increased expression of LRP1 on renal tubular epithelial cells contributes to IRI-induced AKI and TG accumulation. The injury effects of LRP1 on the renal tubules are independent of TG endocytosis. Targeting the inhibition of LRP1 may emerge as a novel therapeutic strategy for AKI.
Authors
- Yuanhan Chen
- Zhilian Li (ORCID: https://orcid.org/0000-0001-5515-5171)
- Xinling Liang (ORCID: https://orcid.org/0000-0002-6764-9571)
- Huaban Liang
- Weiteng Wang (ORCID: https://orcid.org/0000-0001-6480-9325)
- Yingwen Chen (ORCID: https://orcid.org/0000-0002-8171-1861)
- Jintao He (ORCID: https://orcid.org/0000-0003-2083-657X)
- Jieyi Luo
Institutions
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Kidney Diseases
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1159/000545851
- Citations
- 2
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- National Natural Science Foundation of China