Lipopolysaccharide amplifies the endocytosis of circulating exosomes derived from aortic dissection patients by the endothelial cells via a JMJD6 dependent manner
The findings above indicate that LPS co-exposure enhances the AD-exosomes endocytosis by the ECs and further aggravates the inflammatory injury; Targeting on the cellular JMJD6 shall mitigate AD-exosomes endocytosis, which might serve as a potential therapeutic approach for the endothelial dysfunction.
Authors
- Yujing Zhao
- Qi Sun (ORCID: https://orcid.org/0000-0002-0495-1407)
- Junmei Xu (ORCID: https://orcid.org/0000-0001-8700-3842)
- Yulong Cui (ORCID: https://orcid.org/0000-0002-2677-654X)
- Lin Yang (ORCID: https://orcid.org/0009-0001-9864-3893)
Institutions
- Central South University (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- Life Sciences
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1016/j.lfs.2025.123641
- Primary Topic
- Aortic Disease and Treatment Approaches
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province