Innate immune reprogramming in circulating neutrophils of COPD patients
These findings suggest that COPD neutrophils undergo epigenetic, transcriptomic, and metabolic reprogramming, which enhances their responsiveness and aligns with the phenotype of neutrophils previously identified as trained, offering mechanistic insight into the functional dysregulation observed in COPD.
Authors
- C Bracaglia
- Barbara Mariotti (ORCID: https://orcid.org/0000-0001-5831-8319)
- Flavia Bazzoni (ORCID: https://orcid.org/0000-0001-6768-8012)
- Ernesto Crisafulli (ORCID: https://orcid.org/0000-0001-7298-7084)
- Sara Gasperini (ORCID: https://orcid.org/0000-0001-8773-184X)
- Giulia Sartori (ORCID: https://orcid.org/0000-0002-3171-1396)
Institutions
- University of Verona (IT)
- Azienda Ospedaliera Universitaria Integrata Verona (IT)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1016/j.jaci.2025.04.011
- Citations
- 9
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 13.67