Standardized Definition of Progression Independent of Relapse Activity (PIRA) in Relapsing-Remitting Multiple Sclerosis
Incidence and persistence of PIRA are determined by the definition used. The proposed standardized definition aims to enhance comparability among studies.
Authors
- Masoud Etemadifar (ORCID: https://orcid.org/0000-0002-0066-3782)
- Koen de Gans (ORCID: https://orcid.org/0000-0002-8600-0460)
- Richard Macdonell (ORCID: https://orcid.org/0000-0001-6604-3968)
- Bianca Weinstock-Guttman
- Eduardo Agüera (ORCID: https://orcid.org/0000-0002-8604-2054)
- Jiwon Oh (ORCID: https://orcid.org/0000-0001-5519-6088)
- Sifat Sharmin (ORCID: https://orcid.org/0000-0001-7294-9723)
- Neil Shuey
- Dieter Poehlau
- José Luis Sánchez-Menoyo (ORCID: https://orcid.org/0000-0003-2634-8294)
- Daniele Spitaleri (ORCID: https://orcid.org/0009-0009-8290-6781)
- Guy Laureys (ORCID: https://orcid.org/0000-0002-1708-4373)
- Saloua Mrabet (ORCID: https://orcid.org/0000-0003-2718-1828)
- Nevin John (ORCID: https://orcid.org/0000-0002-9834-4498)
- Allan G. Kermode (ORCID: https://orcid.org/0000-0002-4476-4016)
- Radek Ampapa
- Tomáš Kalinčík (ORCID: https://orcid.org/0000-0003-3778-1376)
- Dana Horáková (ORCID: https://orcid.org/0000-0003-1915-0036)
- Mihaela Simu (ORCID: https://orcid.org/0000-0001-9676-1282)
- Talal Al‐Harbi (ORCID: https://orcid.org/0000-0001-5714-6789)
- Patrice H. Lalive (ORCID: https://orcid.org/0000-0003-0607-5778)
- Bassem Yamout (ORCID: https://orcid.org/0000-0002-2540-6651)
- Alessandra Lugaresi (ORCID: https://orcid.org/0000-0003-2902-5589)
- Tamara Castillo‐Triviño (ORCID: https://orcid.org/0000-0002-9249-3185)
- Johannes Lorscheider (ORCID: https://orcid.org/0000-0003-1100-2506)
- William W. Carroll (ORCID: https://orcid.org/0000-0001-7095-2021)
- Anneke van der Walt (ORCID: https://orcid.org/0000-0002-4278-7003)
- Juan Ignacio Rojas (ORCID: https://orcid.org/0000-0002-9747-3626)
- Michael J. Barnett (ORCID: https://orcid.org/0000-0003-4192-4368)
- Sara Eichau (ORCID: https://orcid.org/0000-0001-9159-3128)
- Jens Kühle (ORCID: https://orcid.org/0000-0002-6963-8892)
- Maria Pia Amato (ORCID: https://orcid.org/0000-0003-3325-3760)
- Jannis Müller (ORCID: https://orcid.org/0000-0003-1394-8231)
- Julie Prévost (ORCID: https://orcid.org/0000-0002-8440-8577)
- D. Decoo (ORCID: https://orcid.org/0000-0001-7689-3114)
- Valentina Tomassini (ORCID: https://orcid.org/0000-0002-7368-6280)
- Izanne Roos (ORCID: https://orcid.org/0000-0003-0371-3666)
- Pamela McCombe (ORCID: https://orcid.org/0000-0003-2704-8517)
- Vahid Shaygannejad (ORCID: https://orcid.org/0000-0002-9732-4153)
- Ludwig Kappos (ORCID: https://orcid.org/0000-0003-4175-5509)
- Cameron Shaw (ORCID: https://orcid.org/0000-0001-6218-5440)
- Marzena J. Fabis‐Pedrini (ORCID: https://orcid.org/0000-0002-2614-8607)
- Marie D’hooghe (ORCID: https://orcid.org/0000-0002-0917-4176)
- Samia Joseph Khoury (ORCID: https://orcid.org/0000-0003-3198-6063)
- Özgür Yaldizli (ORCID: https://orcid.org/0000-0002-0800-4845)
- Suzanne Hodgkinson (ORCID: https://orcid.org/0000-0002-9029-6663)
- Justin Garber
- Mark Slee (ORCID: https://orcid.org/0000-0003-4323-2453)
- Melissa Cambron (ORCID: https://orcid.org/0000-0002-6884-2496)
- Jennifer Massey (ORCID: https://orcid.org/0000-0002-3238-4630)
- Matteo Foschi (ORCID: https://orcid.org/0000-0002-0321-7155)
- Bruce Taylor (ORCID: https://orcid.org/0000-0003-2807-0070)
- Aysun Soysal (ORCID: https://orcid.org/0000-0002-1598-5944)
- Recai Türkoğlu (ORCID: https://orcid.org/0000-0001-9724-851X)
- Barbara Willekens (ORCID: https://orcid.org/0000-0002-5212-8837)
- Cristina Ramo‐Tello (ORCID: https://orcid.org/0000-0001-8643-5053)
- Francesco Patti (ORCID: https://orcid.org/0000-0002-6923-0846)
- Tobias J Derfuss (ORCID: https://orcid.org/0000-0001-8656-4250)
- Rana Karabudak (ORCID: https://orcid.org/0000-0003-4272-1482)
- Alexandre Prat (ORCID: https://orcid.org/0000-0001-6188-0580)
- Seyed Mohammad Baghbanian (ORCID: https://orcid.org/0000-0002-8138-7504)
- Abdullah Rashid Al-Asmi (ORCID: https://orcid.org/0000-0002-2851-8157)
- Todd A. Hardy (ORCID: https://orcid.org/0000-0003-4145-3172)
- Mario Habek (ORCID: https://orcid.org/0000-0002-3360-1748)
- Steve Vucic (ORCID: https://orcid.org/0000-0002-8323-873X)
- Riadh Gouider (ORCID: https://orcid.org/0000-0001-9615-3797)
- Oliver Gerlach (ORCID: https://orcid.org/0000-0003-1565-1458)
- Eva Havrdová (ORCID: https://orcid.org/0000-0002-9543-4359)
- Ayşe Altıntaş (ORCID: https://orcid.org/0000-0002-8524-5087)
- Sudarshini Ramanathan (ORCID: https://orcid.org/0000-0002-0294-9768)
- Pascal Benkert (ORCID: https://orcid.org/0000-0001-6525-8174)
- Tünde Csépány (ORCID: https://orcid.org/0000-0002-8305-3209)
- Nikolaos Grigoriadis (ORCID: https://orcid.org/0000-0003-4706-4637)
- Pierre Duquette
- Stephen Reddel (ORCID: https://orcid.org/0000-0002-0169-3350)
- Christopher McGuigan (ORCID: https://orcid.org/0000-0001-8409-710X)
- Cristina Granziera (ORCID: https://orcid.org/0000-0002-4917-8761)
- Thor Petersen (ORCID: https://orcid.org/0000-0001-5633-2600)
- Vincent Van Pesch (ORCID: https://orcid.org/0000-0003-2885-9004)
- Serkan Özakbaş (ORCID: https://orcid.org/0000-0003-2140-4103)
- Claudio Marcello Solaro (ORCID: https://orcid.org/0000-0002-6713-4623)
- Andrea Surcinelli (ORCID: https://orcid.org/0000-0003-3779-0934)
- Yolanda Blanco (ORCID: https://orcid.org/0000-0002-1834-0498)
- Orla Gray (ORCID: https://orcid.org/0000-0002-7799-0116)
- Raed Alroughani
- Bart Van Wijmeersch (ORCID: https://orcid.org/0000-0003-0528-1545)
- María José
- Celia Oreja‐Guevara
- Marc Girard (ORCID: https://orcid.org/0000-0001-8207-8896)
- Elisabetta Cartechini
- Olga Skibina (ORCID: https://orcid.org/0009-0000-1542-5659)
- Katherine Buzzard
- Davide Maimone
- Helmut Butzkueven
- Norma Deri
- Stella Hughes
- Jeannette Lechner-Scott
Institutions
- Isfahan University of Medical Sciences (IR)
- St. Michael's Hospital (CA)
- Cliniques Universitaires Saint-Luc (BE)
- The Royal Melbourne Hospital (AU)
- Barwon Health (AU)
- University of Debrecen (HU)
- Box Hill Hospital (AU)
- Koç University (TR)
- University of Ulster (GB)
- University Hospital Centre Zagreb (HR)
- University of Antwerp (BE)
- İzmir University of Economics (TR)
- The University of Queensland (AU)
- The University of Melbourne (AU)
- Flinders University (AU)
- The University of Western Australia (AU)
- University of Zagreb (HR)
- University of Basel (CH)
- Charles University (CZ)
- Concord Repatriation General Hospital (AU)
- AHEPA University Hospital (GR)
- Ghent University Hospital (BE)
- The Alfred Hospital (AU)
- King Fahad Specialist Hospital (SA)
- Aarhus University Hospital (DK)
- University Hospital of Basel (CH)
- Royal Hobart Hospital (AU)
- Westmead Hospital (AU)
- Amiri Hospital (KW)
- Hospital Clínico San Carlos (ES)
- Hospital de São João (PT)
- Cegep de Saint Jerome (CA)
- UNSW Sydney (AU)
- Maastricht University (NL)
- University of Chieti-Pescara (IT)
- Bakırköy Psychiatric Hospital (TR)
- St Vincent's Hospital Melbourne (AU)
- St Vincent's Hospital Sydney (AU)
- Hunter Medical Research Institute (AU)
- DRK Kamillus Klinik (DE)
- Hospital Universitario Virgen Macarena (ES)
- Hospital Jihlava (CZ)
- Ospedale "Santa Maria delle Croci" di Ravenna (IT)
- Hospital Fernández (AR)
- Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (ES)
- Eastern Health (AU)
- Hospital Universitario Austral (AR)
- Biogipuzkoa Health Research Institute (ES)
- Antwerp University Hospital (BE)
- American University of Beirut Medical Center (LB)
- University Hospital of Geneva (CH)
- Azienda Ospedaliera S.Giuseppe Moscati (IT)
- Hospital Clínic de Barcelona (ES)
- St. Vincent's University Hospital (IE)
- Hospital de Galdakao (ES)
- Don Carlo Gnocchi Foundation (IT)
- Camera de Comerț Industrie și Agricultură Timișoara (RO)
- Monash Health (AU)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- AZ Sint-Jan (BE)
- Hospital Universitario Reina Sofía (ES)
- Haydarpaşa Numune Eğitim ve Araştırma Hastanesi (TR)
- Policlinico Universitario di Catania (IT)
- Royal Victoria Hospital (GB)
- Zuyderland Medisch Centrum (NL)
- Ospedale Cannizzaro (IT)
- Mind Australia (AU)
- Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno (AR)
- Groene Hart Ziekenhuis (NL)
- Ingham Institute (AU)
- Perron Institute for Neurological and Translational Science (AU)
- Sultan Qaboos University Hospital (OM)
- Alma (BE)
- Jacobs Institute (US)
- Yeditepe University Hospital (TR)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Hospital Universitari Germans Trias i Pujol (ES)
- Austin Health (AU)
- South Eastern Health and Social Care Trust (GB)
- Hôpital Razi de La Manouba (TN)
- University of Florence (IT)
- Sultan Qaboos University (OM)
- University of Macerata (IT)
- Monash University (AU)
- Université de Montréal (CA)
- Hasselt University (BE)
- University of Bologna (IT)
Publication Details
- Journal
- JAMA Neurology
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1001/jamaneurol.2025.0495
- Citations
- 22
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 32.38