Síndrome de <i>Cushing</i> e diabetes <i>mellitus</i> secundária em cadela

The aim of this study was to report a case of a 9-year-old SRD female dog with hyperadrenocorticism (HAC) and secondary diabetes mellitus (DM), with emphasis on the laboratory alterations associated with the clinical picture. Cushing's syndrome is an endocrinopathy commonly seen in middle-aged to elderly dogs, uncommon in young animals and rare in cats. This pathology is characterized by a chronic excess in the serum concentration of glucocorticoids, which has immunosuppressive, anti-inflammatory, catabolic and gluconeogenic effects on various systems in the body. At the same time as HAC in dogs, there is a predisposition to developing secondary DM, due to the effect of cortisol causing insulin resistance. Treatment is carried out with the drugs Mitotane, which destroys the gland, or trilostane, which blocks the production of adrenal hormones, and in the latter case the gland is surgically removed. An SRD bitch, 9 years old, black and white coat, 17,300 kg, not neutered, dewormed, vaccinated with a history of hematuria and recurrent urinary tract infection. During the anamnesis, the main complaint was obesity. The person responsible also reported tiredness when walking, polyuria, polydipsia and polyphagia. A low-dose dexamethasone suppression test was carried out and showed cortisol levels above the reference values, confirming the diagnosis of HAC. The treatment with insulin lantus refil® 7 units BID, subcutaneously after eating; Vetoryl® (trilostane) 30 mg, one capsule orally BID for continuous use. Insulin therapy did not prove effective in the current study due to the incorrect insulin prescription for this patient, and the use of trilostane did not prove effective in the treatment of Cushing's syndrome in the current study due to the patient's serious condition.