Comparison of programmed death ligand-1 expression in preoperative transbronchial lung biopsy and resected specimens in non-small cell lung cancer
Programmed death-ligand 1 expression in biopsy and resected specimens is often discordant, often being underestimated in biopsy specimens. Discordance is more likely when tumor cell counts are low in the biopsy samples. Therefore, caution is advised when treatment decisions are made based on programmed death-ligand 1 assessments of small specimens.
Authors
- Shuji Murakami (ORCID: https://orcid.org/0000-0001-5104-5493)
- Tetsuya Isaka (ORCID: https://orcid.org/0000-0002-3302-7133)
- Tomoyuki Yokose (ORCID: https://orcid.org/0000-0002-9403-9592)
- Haruhiro Saito (ORCID: https://orcid.org/0000-0002-8541-8339)
- Kota Washimi
- Yohei Miyagi (ORCID: https://orcid.org/0000-0002-0056-7010)
- Aya Saito (ORCID: https://orcid.org/0000-0001-6731-2007)
- Naoko Shigeta (ORCID: https://orcid.org/0000-0002-0311-5116)
- Kouji Yamamoto (ORCID: https://orcid.org/0000-0003-0696-9659)
- Hiroyuki Ito (ORCID: https://orcid.org/0000-0001-7634-1424)
Institutions
- Kanagawa Prefectural Hospital Organization (JP)
- Kanagawa Cancer Center
- Yokohama City University (JP)
Publication Details
- Journal
- Journal of Cancer Research and Clinical Oncology
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1007/s00432-025-06189-8
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00