Visible Light-Promoted Defluorinative Alkylation of Trifluoromethyl Ketones with α-Aminoalkyl Boron Species

In this study, we developed a photoredox-catalyzed defluorinative cross-coupling method for trifluoroketones and alkyl boronic acids. The reaction afforded a series of novel α,α-difluoroketone derivatives, and <i>in vitro</i> fungicidal activity revealed that some of these compounds exhibited moderate to excellent activity against <i>Rhizoctonia solani</i> and <i>Botrytis cinerea</i>. In particular, compound <b>3d</b> showed an EC₅₀ value of 4.27 μg/mL against <i>B. cinerea</i> and can be used as a fungicidal lead compound for further optimization.