Single-cell profiling reveals monocyte heterogeneity and association with liver fibrosis in patients with chronic HBV
Our data suggest that enhanced LMO2 expression in circulating monocytes may be associated with their expansion, and an increased MPA subset may participate in liver fibrosis progression. These results provide valuable insights into the etiology of liver fibrosis in patients with CHB.
Authors
- Shulei Jia (ORCID: https://orcid.org/0000-0003-2483-0300)
- Wenying Zhao (ORCID: https://orcid.org/0000-0001-8774-144X)
- Wei Sun (ORCID: https://orcid.org/0000-0002-6448-9541)
- Wanzhen Li (ORCID: https://orcid.org/0000-0002-9980-7933)
- Dongming Zhou (ORCID: https://orcid.org/0000-0002-5989-7591)
- Hongzheng Wu
- Min Wang (ORCID: https://orcid.org/0000-0002-3420-4031)
- Yang Li (ORCID: https://orcid.org/0000-0003-3855-7720)
- Sheng Yin (ORCID: https://orcid.org/0000-0002-7253-2191)
- Lifeng Feng (ORCID: https://orcid.org/0000-0001-9537-351X)
- Jiling Ren (ORCID: https://orcid.org/0000-0002-4035-2057)
- Xueyang Pang
- Fang Lei
- Yue Zhuo
Institutions
- Central South University (CN)
- Nankai University (CN)
- Tianjin Centers for Disease Control and Prevention (CN)
- Second Xiangya Hospital of Central South University (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1097/hc9.0000000000000672
- Citations
- 3
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.39