A greater frequency of circulating CCR7loPD-1hi follicular helper T cells indicates a durable clinical cure after Peg IFN-α therapy in chronic hepatitis B patients
Higher frequencies of CCR7loPD-1hi Tfh cells, lower levels of sCTLA-4 as well as sPD-1 in EOT were protective factors for relapse among CHB patients who experienced HBsAg loss after pegylated interferon-alpha therapy. CCR7loPD-1hiTfh cells produced insufficient IL-21 in patients who experienced recurrent disease, which resulted in a decrease in the ability of B cells to produce anti-HBs.
Authors
- Sujun Zheng (ORCID: https://orcid.org/0000-0002-8228-2819)
- Xinyue Chen (ORCID: https://orcid.org/0000-0003-3212-2398)
- Lina Ma (ORCID: https://orcid.org/0000-0002-0867-2341)
- Xiao Lin (ORCID: https://orcid.org/0000-0001-9095-3187)
- Shan Ren (ORCID: https://orcid.org/0000-0001-7673-8018)
- Xiaoxiao Wang (ORCID: https://orcid.org/0000-0002-6296-496X)
Institutions
- Qualcomm (United Kingdom) (GB)
- Beijing YouAn Hospital (CN)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1097/hc9.0000000000000690
- Citations
- 2
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.71