FTO-mediated m6A Demethylation of OTUB1 stabilizes SLC7A11 to alleviate Ferroptosis in cerebral ischemia/reperfusion injury
FTO enhanced OTUB1 expression via m6A demethylation, stabilizing SLC7A11, and inhibiting ferroptosis to alleviate cerebral I/R injury. The FTO/OTUB1/SLC7A11 pathway is a viable therapeutic target for ischemic stroke, providing novel perspectives on the molecular mechanisms underlying neuroprotection and proposing innovative m6A-based therapies.
Authors
- Zhuangzhi Zhou (ORCID: https://orcid.org/0000-0002-4349-2602)
- Wentao Liu (ORCID: https://orcid.org/0000-0001-5534-7173)
- Youjin Shen (ORCID: https://orcid.org/0000-0002-0706-7350)
- Jianwen He (ORCID: https://orcid.org/0000-0002-8390-0834)
- Xiaokun Qi
Institutions
- Chinese PLA General Hospital (CN)
- The First People's Hospital of Zhaoqing (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Stroke and Cerebrovascular Diseases
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1016/j.jstrokecerebrovasdis.2025.108316
- Citations
- 4
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.22