THEORIES OF PATHOGENESIS AND A SIGNIFICANCE OF SPINAL CORD INJURIES IN MULTIPLE SCLEROSIS (LITERATURE REVIEW)

This article describes contemporary views on spinal cord injuries (SCI) in multiple sclerosis (MS), a widespread demyelization of which has a high inflammatory potential and is one of the main determinants of an irreversible disability in progressive course of the disease. The essence of several proposed in different times theories concerning mechanisms of pathogenesis of SCI caused by autoimmune inflammation and atrophy is briefly provided. The presented data about prevalence, diagnostical value, and prognostic significance of SCI in MS underline a necessity not only to take into account a presence of spinal cord autoimmune inflammation and atrophy for determination of the treatment tactics, but also to refuse the principle of an economic feasibility of the visualization of spinal cord if there are no new symptoms associated with its injury.