Neoadjuvant Stereotactic Radiosurgery for Large Brain Metastases: An International, Multicenter, Single-Arm Phase II Trial
In this study, no patients experienced symptomatic RN and the incidence of meningeal failure was lower than historical rates associated with postoperative SRS. However, the high 1-year rate of LF suggests a potential benefit for higher or fractionated radiation doses or larger clinical target volume margins.
Authors
- Daniel Zips (ORCID: https://orcid.org/0000-0001-5779-9675)
- Peter Vajkoczy (ORCID: https://orcid.org/0000-0003-4350-392X)
- Ruth Lau (ORCID: https://orcid.org/0000-0002-8640-2339)
- Julian Spears (ORCID: https://orcid.org/0000-0002-4111-6929)
- Dianna Li
- Carolin Senger (ORCID: https://orcid.org/0000-0001-7700-4657)
- David Shultz (ORCID: https://orcid.org/0000-0001-8242-6555)
- Randa Higazy
- Aristotelis Kalyvas (ORCID: https://orcid.org/0000-0002-0222-488X)
- Normand Laperrière (ORCID: https://orcid.org/0000-0001-8930-9650)
- Gelareh Mohammed Zadeh (ORCID: https://orcid.org/0000-0002-6637-4502)
- Paul N. Kongkham (ORCID: https://orcid.org/0000-0002-1047-9305)
- Güliz Acker (ORCID: https://orcid.org/0000-0002-8946-6426)
- Alejandro Berlín (ORCID: https://orcid.org/0000-0002-1880-6905)
- Enrique Gutiérrez (ORCID: https://orcid.org/0000-0002-3524-2339)
- Mark Bernstein
- Tatiana Conrad
- Barbara‐Ann Millar
Institutions
- St. Michael's Hospital (CA)
- University Health Network (CA)
- Toronto Western Hospital (CA)
- Princess Margaret Cancer Centre (CA)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Neurosurgery
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1227/neu.0000000000003451
- Citations
- 2
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- Princess Margaret Cancer Foundation