Association of serum 25-hydroxyvitamin D with the risk of depression in individuals with prediabetes and diabetes: A prospective cohort study
Over a mean follow-up period of 11.7 years, a total of 2,409 depression events were documented in participants with diabetes; and 6,078 depression events were recorded in the prediabetic participants, during a mean follow-up of 12.3 years. Vitamin D sufficiency (≥75 nmol/L) was observed in only 12.5% of individuals with prediabetes and 11.3% of those with diabetes. After multivariate adjustment, an inverse and dose-dependent relationship was identified between serum 25(OH)D concentrations and the risk of depression in prediabetic and diabetic participants (P trend <0.05). Compared with the lowest 25(OH)D level (<25 nmol/L), the highest level (≥75 nmol/L) exhibited a 17% reduction in the risk of depressive events (HR 0.83; 95% CI 0.75-0.93) among individuals with prediabetes and a 25% reduction (HR 0.75; 95% CI 0.61-0.90) among those with diabetes。 CONCLUSION: The findings of this study highlight the critical importance of prioritizing serum 25(OH)D levels in the management of depression in patients with diabetes and prediabetes.
Authors
- Yingzhou Shi (ORCID: https://orcid.org/0000-0002-0523-0943)
- Yicheng Ma (ORCID: https://orcid.org/0000-0002-9585-6279)
- Ling Gao (ORCID: https://orcid.org/0000-0003-0714-7200)
- Yiping Cheng (ORCID: https://orcid.org/0000-0002-7092-508X)
- Qiang Wang (ORCID: https://orcid.org/0000-0002-7366-5674)
- Peipei Wang (ORCID: https://orcid.org/0000-0001-7201-4928)
- Guodong Liu (ORCID: https://orcid.org/0000-0002-9748-9556)
- Hang Dong (ORCID: https://orcid.org/0000-0002-3332-391X)
- Junming Han
- Yingli Lu
- Shengyu Tian
- Huaxue Li (ORCID: https://orcid.org/0009-0003-7216-9550)
Institutions
- Shandong University (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Ninth People's Hospital (CN)
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- The journal of nutrition health & aging
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1016/j.jnha.2025.100556
- Citations
- 1
- Primary Topic
- Vitamin D Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Shanxi Provincial Postdoctoral Science Foundation
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Shandong Province
- National Key Research and Development Program of China
- National Key Research and Development Program of China Stem Cell and Translational Research
- Shandong Provincial Postdoctoral Science Foundation