Oleanolic Acid@SPIONs Alleviates Lipid-Oxidative Stress Injury of Zebrafish Blood Vessels via Regulating the Expression of JNK and MAPK Signaling Pathways in Vascular Endothelial Cells
Therefore, our results confirm that SPIONs can effectively deliver OA for stable release in zebrafish and provide strong evidence that OA@SPION-polyethyleneimine exerts protective effects against oxLDL-induced damage in zebrafish by downregulating the expression of the JNK and MAPK signaling pathways.
Authors
- Junfeng Liu (ORCID: https://orcid.org/0000-0001-5825-5397)
- Lian Yang (ORCID: https://orcid.org/0000-0002-0646-5971)
- Hongguo Gao
- Lei Liu (ORCID: https://orcid.org/0000-0003-0425-8159)
- Peirong Huang (ORCID: https://orcid.org/0000-0003-2793-1473)
- Te Liu (ORCID: https://orcid.org/0000-0003-3976-3489)
- Xiling Du
- Zeyu Cui
- Yun Gu (ORCID: https://orcid.org/0000-0002-2783-2929)
Institutions
- Jiangxi University of Traditional Chinese Medicine (CN)
- Tongji University (CN)
- Shanghai Business School (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Eye Disease Prevention & Treatment Center (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai First People's Hospital (CN)
- People's Liberation Army 411 Hospital (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/dddt.s512752
- Citations
- 5
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 4.03