Synthesis of Viriditins A and B by Selective Coupling of <i>Trans</i>-1,2-Dichloroethylene
A synthesis of (-)-viriditin A and (-)-viriditin B has been completed sequentially using a Suzuki coupling and a Heck reaction of <i>trans</i>-1,2-dichloroethylene. The selectivity for monocoupling of <i>trans</i>-1,2-dichloroethylene is attributed to a lower-energy transition state for the oxidative addition step.
Authors
- Dániel Csókás (ORCID: https://orcid.org/0000-0002-4150-477X)
- Raghunath O. Ramabhadran (ORCID: https://orcid.org/0000-0001-9938-5446)
- Roderick W. Bates (ORCID: https://orcid.org/0000-0002-8115-4970)
- Sopan Pralhad Khandare
- Feddro Gilbert Wijaya (ORCID: https://orcid.org/0000-0002-0729-3075)
Institutions
- Nanyang Technological University (SG)
- Indian Institute of Science Education and Research, Tirupati (IN)
- HUN-REN Research Centre for Natural Sciences (HU)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1021/acs.joc.4c02975
- Citations
- 2
- Primary Topic
- Plant-based Medicinal Research
- Type
- article
- Field-Weighted Citation Impact
- 3.11
Funders
- Ministry of Education - Singapore
- Nanyang Technological University
- Nemzeti Kutatási Fejlesztési és Innovációs Hivatal