Differences in Fatty Acid Metabolism between MCDD and HFD Induced Metabolic Dysfunction-associated Fatty Liver Disease Model Mice
Impaired fatty acid oxidation and increased hepatic fatty acid uptake play key roles in the pathogenesis of the two MAFLD models. The inverse changes in de novo lipogenesis and fatty acid efflux may represent an important pathological mechanism that leads to the phenotypic differences between the MCDD and HFD models.
Authors
- Guoxiang Xie (ORCID: https://orcid.org/0000-0002-0951-4150)
- Xiaoning Wang (ORCID: https://orcid.org/0000-0003-0153-324X)
- Zhen Guo (ORCID: https://orcid.org/0000-0003-4022-7755)
- Qi Li (ORCID: https://orcid.org/0000-0002-9144-148X)
- Jia Liu (ORCID: https://orcid.org/0000-0002-6957-3814)
- Ping Liu (ORCID: https://orcid.org/0000-0002-3039-5985)
- Jiaxuan Wang (ORCID: https://orcid.org/0009-0008-0450-6857)
- Huilin Zhang
- Xinzhu Liu (ORCID: https://orcid.org/0009-0000-8375-7268)
Institutions
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Yueyang Hospital (CN)
- Shuguang Hospital (CN)
Publication Details
- Journal
- Biological Procedures Online
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1186/s12575-025-00276-3
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China