Healthy lifestyle factors outweigh influence of APOE genetic risk on extending cognitively healthy life expectancy among Chinese older adults: evidence from a nationwide cohort study
Compared with ε3 homozygotes, APOE ε4 carriers in China have a higher risk of transitioning from CH to CI, and APOE ε2 carriers with CH have a lower risk of transitioning to death. Healthy lifestyles can extend life expectancy, primarily extending CH life expectancy. Healthy lifestyles reduce the risk of CI and delay its onset in later life, regardless of APOE genetic risk.
Authors
- Sebastian Walsh (ORCID: https://orcid.org/0000-0001-8894-5006)
- Mingzhi Yu (ORCID: https://orcid.org/0009-0001-2098-8082)
- Longbing Ren (ORCID: https://orcid.org/0000-0003-2462-2421)
- Quincy M. Samus (ORCID: https://orcid.org/0000-0001-8218-7769)
- Shaojie Li (ORCID: https://orcid.org/0000-0001-6791-3216)
- Yi Zeng (ORCID: https://orcid.org/0000-0001-5610-8107)
- Xurui Jin (ORCID: https://orcid.org/0000-0002-8111-109X)
- Yuling Jiang (ORCID: https://orcid.org/0009-0003-8227-2228)
- Gill Livingston (ORCID: https://orcid.org/0000-0001-6741-5516)
- Huashuai Chen (ORCID: https://orcid.org/0000-0001-9535-8299)
- Yao Yao (ORCID: https://orcid.org/0000-0002-6723-6152)
- Yifei Wu (ORCID: https://orcid.org/0000-0003-1430-7081)
- Yang Hu (ORCID: https://orcid.org/0000-0001-5900-7432)
- Jing Sun (ORCID: https://orcid.org/0000-0002-9749-6801)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-9970-1821)
- Keyang Liu (ORCID: https://orcid.org/0000-0001-8948-5590)
- Kokoro Shirai (ORCID: https://orcid.org/0000-0002-7014-817X)
- Fan Hu (ORCID: https://orcid.org/0009-0009-2383-6007)
- Grace Yuange Zang
Institutions
- Johns Hopkins University (US)
- Duke University (US)
- Anhui Medical University (CN)
- Peking University (CN)
- University of Cambridge (GB)
- Johns Hopkins Medicine (US)
- Chinese PLA General Hospital (CN)
- University College London (GB)
- Xiangtan University (CN)
- The University of Osaka (JP)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/alz.70090
- Citations
- 6
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 8.83
Funders
- National Natural Science Foundation of China
- National Science and Technology Major Project